The abstract is read at the publisher; the summary is JClub's.
In the LASCOPE cohort at Federal Medical Centre Owo, pregnant women with PCR-confirmed Lassa fever had comparable 28-day all-cause mortality (9% vs 7%) to non-pregnant women.
- Why it matters: Evidence for maternal and perinatal outcomes in Lassa fever has relied on small case series, leaving uncertainty about maternal risk and the timing-related fetal prognosis.
- What they did: The study analyzed 45 pregnant versus 258 non-pregnant women of childbearing age (15–45 years) with PCR-confirmed Lassa fever, using Kaplan-Meier/Cox models for 28-day mortality and competing-risk estimation for fetal death.
- The result: Fetal case-fatality was 60% (27 of 45), with fetal death linked to earlier infection (100% first trimester; odds ratio per additional week of gestation at symptom onset 0·77).
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.