VAMP725 and VAMP726 interact with cellulose synthase to support secondary cell wall formation.

VAMP726 associates with multiple CESA proteins and is codelivered to the plasma membrane, where it colocalizes with CESA during cellulose synthesis in plant tissues.

• Why it matters: Cellulose synthesis depends on CESA complexes reaching and persisting at the plasma membrane, but the intracellular trafficking machinery that supports this process is not well defined.
• What they did: The study used protein interaction and localization analyses to test whether VAMP726 and VAMP725 associate with CESA proteins, then assessed how VAMP function affects CESA trafficking and cellulose synthesis in growing and secondary wall–producing tissues.
• The result: VAMPs, especially VAMP726, are important for CESA trafficking and for sustaining cellulose synthesis in both growing tissues and maturing secondary wall tissues, supporting a trafficking role for VAMP proteins.

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