Single-cell and spatial transcriptomics of cellular heterogeneity in Alzheimer disease.

Single-cell and spatial transcriptomics show that Alzheimer disease brain heterogeneity is linked to stage-dependent glial remodeling and disrupted cell-cell communication networks.

• Why it matters: Canonical amyloid plaques and neurofibrillary tangles do not explain the clinical, regional, and cellular variability of Alzheimer disease, which is shaped by multicellular interactions in distinct microenvironments.
• What they did: The work integrates single-cell/single-nucleus RNA sequencing to profile individual cell populations and spatial transcriptomics or multiplexed imaging to map transcriptional changes onto tissue context.
• The result: These approaches enable linking molecular signatures to anatomical location and stage, supporting precision translational pipelines such as multi-omic benchmarking of animal models and single-cell-based drug-repurposing strategies.

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