Network disruption in post-stroke depressive symptoms: a Bayesian multicohort study.

Right frontal lesions and right-dominant frontal cortico-subcortical structural disconnection are most strongly associated with post-stroke depressive symptoms across 1,864 stroke patients.

• Why it matters: Lesion-location studies of post-stroke depression have been inconsistent, and Bayesian evidence can weigh associations against null findings across brain regions.
• What they did: The authors reanalyzed four observational cohorts (France, Korea, Germany, USA; 1,864 patients) using voxel-wise Bayes factor mapping with general linear models, plus structural disconnection and functional lesion network mapping from normative connectome data.
• The result: They found lesion-linked clusters in the right hemisphere (including frontal, insular, parietal cortex and striatum, amygdala, hippocampus) and widespread evidence of no contribution in the left hemisphere; structural disconnection implicated bilateral frontal white matter (corpus callosum, anterior thalamic radiation), while network mapping linked symptoms to left posterior cingulate cortex/precuneus and less consistently bilateral anterior insula.

AI summary of the abstract · may contain errors · not medical advice · read the paper.