Nat GenetJClub
Longitudinal single-cell profiling of breast tumors highlights immune and epigenetic mechanisms associated with sensitivity to aromatase inhibitors.
Nature Genetics · · Journal Article · Open access
Altinönder, Winton + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
In 25 ER-positive breast cancer patients, single-cell profiling links high ER signaling and ER-bound enhancer activity to sensitivity to neoadjuvant aromatase inhibitors.
- Why it matters: Mechanisms of response versus resistance to aromatase inhibitors in ER-positive tumors are unclear, limiting prediction and targeted adaptation during neoadjuvant therapy.
- What they did: Tumor biopsies were profiled longitudinally with single-cell RNA sequencing, immune receptor sequencing, and enhancer activity mapping across neoadjuvant treatment.
- The result: Resistance is associated with androgen receptor signaling, dedifferentiation, and epithelial-mesenchymal transition, while baseline microenvironment and immune clonality relate to tumor downstaging and response.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.
- Open access