WCRC-25: A novel luminal Invasive Lobular Carcinoma cell line model

WCRC-25, an invasive lobular carcinoma cell line from a patient pleural effusion, shows luminal Her2-like features and confirmed PI3K/AKT inhibitor sensitivity.

• Why it matters: Invasive lobular carcinoma is understudied because few cell lines exist, limiting mechanistic work on its discohesive, single-file biology and therapeutic vulnerabilities.
• What they did: The team established WCRC-25 from metastatic ILC pleural effusion, profiled it by sequencing, copy-number/optical genome mapping, transcriptomics, and functional assays including PI3K/AKT inhibition and migration toward Collagen I.
• The result: WCRC-25 carries a CDH1 Q706* truncating mutation and shares key mutations with patient metastases, predicts AKT-pathway dependence, and in vivo engrafts and spontaneously metastasizes.

AI summary of the abstract · may contain errors · not medical advice · read the paper.