Cell size asymmetry regulates neural stem cell proliferation and lineage expansion in the Drosophila brain.

Altering cell size asymmetry in Drosophila neural stem cells expands the NSC pool while restricting lineage expansion, with Imp and CycE upregulated and Prospero asymmetrically inherited.

• Why it matters: Cell size asymmetry is known to generate unequal sibling sizes, but how it shapes stem-cell proliferation versus lineage expansion in vivo is not well defined.
• What they did: Using live-cell imaging, NSC lineage analysis, and gene expression profiling in Drosophila, they manipulated CSA and tested two ODE model mechanisms: NSC volume sensitivity and NSC self-inhibition.
• The result: The volume-sensitivity mechanism is supported by increased Imp and CycE in NSCs with altered CSA, while Prospero asymmetry in symmetrically dividing NSCs suggests self-inhibition, linking cell size and fate determinants to neurogenesis.

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