RACK1 links immune signaling and translation during host-pathogen interactions.

RACK1 is positioned as a central hub that integrates immune signaling, translational control, and stress responses at the host-pathogen interface.

• Why it matters: Infectious disease outcomes depend on host defense and pathogen virulence, but RACK1’s roles across different infections remain fragmented and pathogen-specific.
• What they did: This review consolidates structural and cellular functions of RACK1 in host defense and surveys pathogen strategies that exploit RACK1-dependent pathways during infection.
• The result: By integrating findings across diverse infectious systems, it clarifies how RACK1 may shape infection outcomes and highlights therapeutic potential and future research directions.

AI summary of the abstract · may contain errors · not medical advice · read the paper.