Predicting responses to prebiotic fibres: linking microbiota, function and clinical outcomes.

Individual responses to prebiotic and fermentable fibres vary widely in gut microbiota composition and function, limiting population-wide efficacy and motivating predictive strategies.

• Why it matters: This variability makes dietary interventions less reliable across people, creating a key challenge for improving clinical utility of prebiotic fibres.
• What they did: The Review synthesizes reasons for individualized microbiota and clinical responses and outlines approaches using systems biology, mechanistic modelling, and machine learning to predict and optimize treatment effects.
• The result: Integrating microbiota–fibre interaction mechanisms and fibre physicochemical structure is proposed to reduce inter-individual variability and improve clinical efficacy of prebiotic fibres.

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