Hippocampal-prefrontal cortical interactions and neural representations of memory.

Bidirectional hippocampal–medial prefrontal cortex communication is linked to how memory representations are formed, maintained, and used during learning and recall.

• Why it matters: Memory storage and decision-making require hippocampal cooperation with cortex, but the specific representations and neural activity patterns enabling this interaction remain unclear.
• What they did: This review synthesizes evidence addressing what information is represented in hippocampus and mPFC, which activity patterns and brain states support their communication, and how these relate to learning in new versus familiar settings.
• The result: The authors summarize findings supporting bidirectional communication during and after experience, outlining open questions for determining how these interactions shape neural representations of memory.

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