Timing of Long COVID Improvement in Prospectively Followed RECOVER-Adult Participants.

In RECOVER-Adult participants with likely Long COVID (LCRI ≥11) 12 months after first SARS-CoV-2 infection, 50.1% had LCRI <11 at two consecutive visits by 36 months.

• Why it matters: Long COVID is widespread, but clinicians lack clear estimates of how often and how quickly symptoms remit over time in prospectively followed cohorts.
• What they did: In a prospective multisite cohort across 83 U.S. sites, 1019 participants were followed, and time to symptom improvement was defined by two consecutive visits with LCRI <11.
• The result: By 36 months, 56.4% reached a ≥50% LCRI reduction and 26.9% reached LCRI = 0, supporting natural recovery trajectories and informing future therapeutic trial timing.

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