Multi-omics profiling of the choroid plexus reveals developmental cellular remodeling, early immune gene activation, and epithelial cell heterogeneity.

Multi-omics analysis reveals dynamic cellular remodeling and immune gene activation in the choroid plexus across postnatal to adult stages in mice and rats.

• Why it matters: Understanding how the choroid plexus develops and functions is crucial because it influences immune cell trafficking and cerebrospinal fluid composition, impacting brain health and disease.
• What they did: The study used bulk and single-cell transcriptomics and epigenomics to profile the lateral ventricle choroid plexus at multiple developmental stages, identifying changes in cell composition, gene expression, and chromatin accessibility.
• The result: Findings include early and progressive activation of immune-related genes, developmental remodeling of epithelial cells with distinct gene programs, and the discovery of a unique epithelial cell population, creating a comprehensive transcriptional and chromatin accessibility atlas.