The global patent landscape of CRISPR-Cas applications in medicine.

Nature Biotechnology · 1 Oct 2026 · Journal Article

Yu, Zhang + more

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An engineered, compact Cas12m variant for multiplexed gene activation in vivo.
Nature Biotechnology · 28 Oct 2026 · Journal Article
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An engineered denCas12m enables smCRISPRa to process a multi-gRNA array into functional guides in vivo, supporting up to eight crRNAs for activating six genes from one AAV vector in mice.
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Prime editing enables drug-controllable T-cell therapies with clinical immunosuppression.
Blood · 5 Nov 2026 · Journal Article
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Multiplex prime editing creates T cells with defined drug resistance, enabling selective in vivo expansion and rapid pharmacologic suppression in humanized mouse models under immunosuppression.
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https://jclub.com.au/a/42523019
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Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells.
Nature Biotechnology · 17 Aug 2026 · Journal Article
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SLICeVLP enables efficient, high-viability CRISPR editing and pooled loss-of-function/ Perturb-seq screening in primary human macrophages, identifying TNFAIP3 as a central regulator of inflammatory polarization.
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The global patent landscape of CRISPR-Cas applications in medicine.

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An engineered, compact Cas12m variant for multiplexed gene activation in vivo.

Prime editing enables drug-controllable T-cell therapies with clinical immunosuppression.

Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells.

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