Diverse infections transcriptionally reprogram the intestinal epithelium and epithelial-immune cell interactions.

GutPath reveals over 500,000 single-cell profiles, uncovering pathogen-specific transcriptional responses and a novel enterocyte state during ileal infections.

• Why it matters: Understanding cellular responses in the ileum is crucial because this region is key to nutrient regulation and is affected in diseases like Crohn's, yet its infection responses are poorly characterized.
• What they did: The study compiled an atlas of RNA and protein data from more than 500,000 cells across diverse infections, identifying immune responses and a new enterocyte state linked to Yersinia pseudotuberculosis.
• The result: This resource enables detailed insights into intestinal cellular diversity and pathogen interactions, paving the way for improved understanding and treatment of intestinal infections and inflammatory diseases.