The abstract is read at the publisher; the summary is JClub's.
Intermittent treatment pulses in structured yeast populations transiently reconfigure the resource landscape, enabling resistant mutants to escape spatial confinement and drive therapy failure.
- Why it matters: Treatment can reshape spatial organization in biofilms and solid tumours, but the mechanisms linking treatment schedules to resistance escape remain unclear.
- What they did: The authors built a spatial evolution assay using populations expanding from single, genetically tailored yeast cells, tracking spatiotemporal trajectories of emerging resistant mutants under intermittent treatment, then fit a real-to-sim-to-real computational model.
- The result: The model and experiments identify a dynamic, phase-transition-like boundary in schedule space that marks a candidate optimal balance between population control and sustained resistance confinement.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.