Generation of two human induced pluripotent stem cell lines from patients with hypokalemic periodic paralysis.

Two human iPSC lines from HypoPP patients carrying the CACNA1S c.1583G>A (p.Arg528His) mutation were generated and characterized for research use.

• Why it matters: HypoPP is caused by a specific mutation affecting muscle ion channels, leading to episodic paralysis and hypokalemia, but models for studying this disorder are limited.
• What they did: Researchers created two iPSC lines, SCVIi152-A and SCVIi153-A, from patients with HypoPP, confirming their pluripotency, normal karyotype, and ability to differentiate into all three germ layers.
• The result: These iPSC lines serve as valuable resources for modeling HypoPP, enabling further investigation of disease mechanisms and potential therapies.