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Intestinal Serotonergic Vagal Signaling as a Mediator of Microbiota-Induced Hypertension.
Circulation · · Journal Article
de Araujo, Sree Kumar + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Intestinal 5-HT and vagal 5HT3a receptor signaling are decreased in hypertensive rats and humans, and restoring colon-innervating vagal 5HT3a signaling can alleviate hypertension.
- Why it matters: Gut dysbiosis is linked to blood pressure, but the neural mechanism connecting intestinal microbiota to host blood pressure homeostasis is unclear.
- What they did: The study used fecal microbiota transplantation between normotensive and hypertensive rats, intersectional 5HT3a receptor Cre genetics to activate/ablate/restore serotonin-sensing colonic vagal neurons, in vivo calcium imaging, radiotelemetric blood pressure, and intestinal 5-HT/5HT3a signaling assays in rats and human biopsies (N=5 per group; 36–75 years).
- The result: Hypertensive rats and humans showed reduced intestinal 5-HT and vagal 5HT3a signaling, and microbiota transfer from hypertensive rats reproduced this; reestablishing 5-HT signaling in colon-innervating vagal neurons alleviated hypertension.
The findingWhy it mattersWhat they didThe result
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