Caloric restriction modulates genome-wide somatic mutation in mice.

Caloric restriction in mice reduces genome-wide somatic mutation burdens by up to a significant extent across multiple tissues and cell types.

• Why it matters: Genomic instability from somatic mutations is a hallmark of aging, and understanding how diet influences this process could reveal strategies to promote healthy aging.
• What they did: Using high-fidelity duplex DNA sequencing, the study analyzed mutation burdens in liver, kidney, hepatocytes, and cerebellar neurons, comparing mice with and without caloric restriction.
• The result: CR decreased both substitution and insertion/deletion mutation burdens, notably reducing activity of SBS5 mutations, especially in transcriptionally inactive regions, thus linking diet to genomic integrity.

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