Nucleoporins in Cancer: Functional Roles and Therapeutic Opportunities.

Nucleoporins (NUPs) dysregulate nuclear pore complex functions in cancer, linking altered nucleocytoplasmic transport, chromatin/transcription, and genome stability to tumor initiation and progression.

• Why it matters: Cancer cells rely on nucleocytoplasmic transport, chromatin regulation, and genome stability, so tumor co-option of NUP-controlled processes can drive malignancy and create therapeutic targets.
• What they did: This review synthesizes mechanistic evidence for how NUP dysregulation contributes to tumor initiation/progression and outlines therapeutic strategies, including clinical-grade molecular glues for selective NUP degradation and pharmacologic inhibition of NPC-regulated signaling and transport.
• The result: The compiled findings support targeting NUPs and NPC-regulated mechanisms with innovative anticancer therapies, offering a rationale for developing treatments that disrupt tumor-relevant nuclear functions.

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