Arrhythmic Risk Stratification According to LGE Corridors and Genetics in Nonischemic Dilated Cardiomyopathy.

In 925 patients with nonischemic dilated cardiomyopathy, having more LGE corridors and high-risk genotypes is independently linked to major ventricular arrhythmic events.

• Why it matters: Current risk stratification relies heavily on left ventricular ejection fraction, leaving uncertainty about which patients with nonischemic disease are most likely to experience ventricular arrhythmias.
• What they did: Across 22 European centers, investigators combined cardiac MRI LGE corridor counts with genetic testing, then used multivariable competing-risk models and a cutoff of ≥4 LGE corridors to predict MVA.
• The result: Over a median 5.4 years, 10.3% had MVA, and an integrated stepwise algorithm improved prediction versus an ejection fraction ≤35% approach (5-year AUC 0.72 vs 0.57).

AI summary of the abstract · may contain errors · not medical advice · read the paper.