Tabula Sapiens 2.0: A comprehensive transcriptomic atlas of human cell types.

Tabula Sapiens 2.0 expands the reference human cell atlas with nine new donors, doubles the number of cells, and adds four new tissues.

• Why it matters: A major need is a larger, better-controlled single-cell transcriptomic reference across many organs to support analyses of gene regulation and aging.
• What they did: The atlas integrates single-cell transcriptomic data from more than two dozen organs and tissues, including donors spanning multiple organs to control genetic background, age, and epigenetic effects.
• The result: It captures transcripts from nearly all human transcription factors and analyzes senescence-associated canonical gene–expressing cells, revealing heterogeneity and context-dependent senescence.

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