The abstract is read at the publisher; the summary is JClub's.
A mechanism-informed read-across model for 69 strict-acid PFAS predicts developmental and reproductive endpoints with MAE 1.41 log10 units on a shared target subset, trading accuracy for lower coverage.
- Why it matters: Comparable developmental and reproductive toxicity points of departure are missing for most PFAS, so a screening method is needed that prioritizes testing while keeping prediction separate from regulatory hazard classification.
- What they did: The EPA CompTox EPAPFASINV inventory was standardized and linked to ToxCast bioactivity across seven nuclear-receptor and thyroid-related pathway groups, then three GenRA-style read-across models were evaluated against eight PFAS with rat oral developmental or reproduction/developmental endpoints.
- The result: In hierarchical screening, 44 of 61 data-poor PFAS received predictions, with 14 high, 19 moderate, 11 lower, and 17 insufficient evidence; most ether replacement PFAS lacked same-class in vivo source endpoints.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.