The abstract is read at the publisher; the summary is JClub's.
Adult male Pelophylax nigromaculatus exposed to tire wear particle leachates for 21 days show significant hepatic lipid droplet accumulation, with elevated triglycerides, total cholesterol, and low-density lipoprotein cholesterol.
- Why it matters: Tire wear particle leachates are emerging aquatic contaminants, but their impacts on amphibian lipid metabolism are not well defined.
- What they did: Adult male frogs were exposed for 21 days to 0, 0.0005, 0.005, 0.05, and 0.5 mg/mL TWP leachates, then hepatic lipid metrics and untargeted LC-MS metabolomics were analyzed.
- The result: Metabolomics and pathway analysis linked TWP exposure to disrupted energy metabolism (TCA cycle and oxidative phosphorylation) and lipid metabolism (glycerophospholipid and sphingolipid pathways), suggesting mitochondrial energy metabolism disturbance associated with hepatic lipid accumulation.
The findingWhy it mattersWhat they didThe result
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