Multimodal brain cell atlas across the adult macaque lifespan.

A multimodal atlas of 2,955,873 nuclei from eight brain regions in 23 female cynomolgus macaques reveals cell-subtype- and region-specific age changes, including a pons/medulla aging hotspot.

• Why it matters: Brain aging mechanisms in non-human primates remain incompletely mapped across regions and cell types, limiting how well molecular vulnerability and regulatory programs can be linked to disease.
• What they did: The study generated high-throughput single-cell transcriptomic and chromatin accessibility data across the adult lifespan, then analyzed dynamic age-related changes and integrated results with human aging/neurodegeneration datasets.
• The result: It identifies multicellular networks in the pons and medulla as a hotspot and highlights white matter vulnerability, while defining transcription factors and age-related chromatin remodeling programs linked to longevity and neurodegeneration.

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