The abstract is read at the publisher; the summary is JClub's.
Lower fecal short-chain fatty acids in mother-infant dyads are not associated with progression to islet autoimmunity, with similar SCFA profiles in cases and matched controls.
- Why it matters: Because reduced microbial SCFA have been linked to type 1 diabetes risk, it is important to test whether lower fecal SCFA during pregnancy and early childhood predicts islet autoimmunity onset.
- What they did: In the ENDIA pregnancy-birth cohort, a nested case-control analysis (n=54 IA cases; n=161 matched controls) quantified fecal SCFA by liquid chromatography-mass spectrometry in 1,120 stool samples from pregnancy trimesters and early life.
- The result: Fecal SCFA were not associated with IA onset, and infant SCFA rose until age 1 year; solid foods increased acetate and summed primary SCFA, while maternal T1D related to lower infant acetate, butyrate, and propionate.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.