Chronic Stress-Induced m7G Cap Modification of ADRB2 Dysregulates the Pentose Phosphate Pathway to Promote Esophageal Squamous Cell Carcinoma Progression.

Chronic stress–linked features in esophageal squamous cell carcinoma patients are associated with pentose phosphate pathway enrichment and elevated epinephrine, alongside ADRB2-driven upregulation of PPP enzymes.

• Why it matters: The work addresses how chronic stress reshapes cancer metabolism, and seeks the molecular bridge between stress signals and metabolic reprogramming in ESCC.
• What they did: The authors used untargeted metabolomics on ESCC patient serum and integrated it with clinical and stress-related assessments; they also tested a pathway where chronic stress activates ADRB2, stabilizes MYCBP, and increases RNMT-dependent m7G cap modification of ADRB2 mRNA, boosting translation and PPP enzymes including G6PD and TKT.
• The result: The findings define an RNMT–ADRB2–MYCBP–PPP axis that links epitranscriptomic regulation with adrenergic signaling to promote metabolic reprogramming and malignant progression in ESCC, suggesting therapeutic targets.

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