Post-transcriptional regulation of allele-specific expression.

Allele-specific expression is shaped not only by cis and epigenetic transcriptional control but also by post-transcriptional mechanisms, with m6A and A-to-I editing highlighted as key epitranscriptomic links.

• Why it matters: The field has characterized how allele-specific transcription arises, but how those allele-specific effects propagate through RNA structure, processing, translation, and decay remains less understood.
• What they did: This review synthesizes evidence across the RNA life cycle—RNA structure, RNA-binding proteins, splicing, polyadenylation, translation, and decay—emphasizing N6-methyladenosine (m6A) and A-to-I editing.
• The result: It highlights widespread sequence-dependent m6A and parent-of-origin-dependent m6A, suggesting an epigenomic-to-epitranscriptomic imprint transmission mechanism, and notes long-read sequencing enables multidimensional ASE views.

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