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mTOR signaling regulates demand-adapted hematopoiesis and metabolic reprogramming required for an effective cellular immune response in Drosophila melanogaster larvae.
PLOS Genetics · · Journal Article · Open access
Anderl, Ekström + more
Abstract ↗AI summary
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mTOR signaling in peripheral larval hemocytes of Drosophila melanogaster induces lamellocyte differentiation, matching parasitoid wasp infection and linking mTOR to immune cell fate control.
- Why it matters: The study addresses how a conserved nutrient-sensing pathway coordinates hematopoiesis and metabolic reprogramming to support an effective cellular immune response.
- What they did: Using genetic and transcriptomic analyses of larval blood cells, the authors compared wasp-infected hemocytes with mTor overexpression and tested pathway order via genetic epistasis.
- The result: Lamellocyte hematopoiesis downstream of mTOR is mediated by JNK and p38, and activation is associated with shifts toward aerobic glycolysis, oxidative pentose phosphate for NADPH, ROS/detoxification, and glutaminolysis.
The findingWhy it mattersWhat they didThe result
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