The abstract is read at the publisher; the summary is JClub's.
Behavioural rigidity is pervasive across dementia subtypes, most pronounced in bvFTD and linked to nucleus accumbens grey matter intensity and connectivity in a 204-participant cross-sectional cohort.
- Why it matters: The neural basis and prevalence of behavioural rigidity across dementia syndromes are unclear, limiting transdiagnostic screening and mechanistic targets for neurodegenerative care.
- What they did: In 110 frontotemporal dementia, 53 Alzheimer’s disease, and 41 healthy older controls, rigidity was measured with the Cambridge Behavioural Inventory-Revised Stereotypical and Motor Behaviour subscale; voxel-based morphometry informed seed-based resting-state connectivity using bilateral nucleus accumbens.
- The result: Across the entire patient sample, behavioural rigidity showed a significant negative association with grey matter intensity exclusively in the bilateral nucleus accumbens, and higher rigidity was associated with stronger left nucleus accumbens connectivity to the left supplementary motor area, paracentral lobule, and precuneus.
The findingWhy it mattersWhat they didThe result
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