Oleic acid promotes lung injury in hypertriglyceridaemia-associated acute pancreatitis via the PIEZO1/NR4A1/CPT1A axis impairing endothelial fatty acid oxidation.

Oleic acid worsens lung injury in hypertriglyceridaemia-associated acute pancreatitis by impairing endothelial fatty acid oxidation through the PIEZO1/NR4A1/CPT1A pathway.

• Why it matters: Understanding how free fatty acids like oleic acid contribute to lung injury in acute pancreatitis is crucial for developing targeted treatments, as current mechanisms are unclear.
• What they did: The study analyzed clinical samples, used a mouse model, and stimulated human endothelial cells to investigate the relationship between plasma oleic acid and lung injury, focusing on the PIEZO1 pathway and fatty acid oxidation.
• The result: Elevated plasma oleic acid was linked to increased lung injury severity, with the PIEZO1/NR4A1/CPT1A axis identified as a key mediator; endothelial-specific PIEZO1 knockdown reduced lung injury, highlighting potential therapeutic targets.