Compressive pangenomics using mutation-annotated networks.

Nature Genetics · 1 Feb 2026 · Journal Article

Walia, Motwani + more

The abstract is read at the publisher; the summary is JClub's.

PanMAN provides a lossless pangenome representation that compresses variation-preserving formats by 3.5–1,391× in file size while encoding mutational and evolutionary histories across genomes.

Why it matters: Existing pangenomic formats struggle to scale to millions of genomes and often focus on variation alone, missing mutational events and evolutionary relationships needed for deeper insight.
What they did: The authors introduce PanMAN and infer detailed mutational and evolutionary histories across genomes, then demonstrate it on a SARS-CoV-2 pangenome built from 8 million sequences using 366 MB.
The result: PanMAN enables new biological insights from mutation-annotated evolutionary histories and, with panmanUtils, supports analyses and interoperability for large-scale pangenomic data sharing.

AI summary of the abstract · may contain errors · not medical advice · read the paper.

5 cites

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Compressive pangenomics using mutation-annotated networks.

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AllTheBacteria: a community resource empowers biology and discovers novel peptide antibiotics

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