The abstract is read at the publisher; the summary is JClub's.
ACE-engineered human iPSC-derived neutrophils (ACE-iNeu) show enhanced bactericidal activity and, after adoptive transfer, significantly lower bacterial burdens in neutropenic mice.
- Why it matters: Severe neutropenia leads to life-threatening infections, and donor granulocyte transfusions are constrained by availability and variable quality.
- What they did: Human iPSCs were engineered to constitutively or inducibly express angiotensin-converting enzyme (ACE), then differentiated into ACE-iNeu; their maturation, reactive oxygen species, cytokines, and antimicrobial signaling were tested, including against methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas aeruginosa.
- The result: ACE expression increased granulocytic maturation and antimicrobial functions, and ACE-iNeu reduced circulating and tissue bacterial burdens in neutropenic mice; metabolomic and transcriptomic profiling linked ACE-associated changes in adenine nucleotide abundance and developmental and inflammatory pathways.
The findingWhy it mattersWhat they didThe result
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