OpenDrive: An Open-Source Microdrive for Large-Scale Neurophysiology

OpenDrive is an open-source microdrive system for acute insertion of Neuropixels-NHP probes that has supported recordings from thousands of neurons across cortical and subcortical structures.

• Why it matters: High-density Neuropixels-NHP recording in large animals is limited by technical and cost barriers from existing microdrive options.
• What they did: The team built a custom motorized microdrive, six-drive control console, and software platform, then compared it with commercially available options on cost and movement performance.
• The result: OpenDrive is linked to low cost, precise and stable probe movement, scalability to many-probe recordings, and community-driven hardware/software development, enabling faster Neuropixels adoption in large animal models.

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