The abstract is read at the publisher; the summary is JClub's.
Daily Lactobacillus-derived postbiotic LB fermentate HF (LBHF) in older cats did not change intestinal permeability versus placebo, despite higher permeability being linked to age.
- Why it matters: Aging cats show reduced nutrient digestibility and higher intestinal permeability, but microbiome-targeted postbiotic evidence in older cats is limited.
- What they did: In a blinded, placebo-controlled crossover trial (29-day LBHF vs placebo, 28-day washout) with 20 cats aged 7.7–13.8 years (18 completed), intestinal permeability was the primary endpoint and digestibility, microbiome, and metabolomics were secondary.
- The result: LBHF increased overall nutrient digestibility, with the clearest endpoint-specific effect on protein digestibility, while producing modest, non-significant microbiome shifts (including reduced Streptococcus lutetiensis) and significant but sequence-dependent fecal and plasma metabolite changes.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.