Patterns of Childhood Exposomes, White Matter Development and Behaviors Link to Future Cognition and Psychopathology in Youth

Two latent exposome–white matter–behavior dimensions in 8,113 preadolescents link socioeconomic resources or psychosocial support to distinct white matter development, cognition, and psychopathology patterns.

• Why it matters: Childhood exposures co-occur as a correlated exposome, but how these multidimensional patterns jointly relate to white matter development and later cognition or psychiatric risk is unclear.
• What they did: Using regularized multiset canonical correlation analysis on longitudinal Adolescent Brain Cognitive Development data, the study derived two multivariate dimensions spanning exposures, tract-wise white matter measures, and multi-domain behaviors, then tested concurrent and follow-up outcomes.
• The result: Longitudinal models showed differential contributions of each dimension to later cognitive, socioemotional, and psychiatric outcomes, and white matter/exposomic variates moderated childhood adversity’s transdiagnostic disorder risk in sex- and context-specific ways.

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