PNEUMOCOCCAL CONJUGATE VACCINE SCHEDULES SHAPE SEROTYPE-SPECIFIC MEMORY B-CELL RESPONSES

In Vietnamese infants, PCV13 and 1+1 schedules induce robust serotype-specific memory B-cell responses, with PCV13 generating earlier and higher BMEM than PCV10.

• Why it matters: Reduced-dose PCV schedules are endorsed under specific conditions, but infant trial data on serotype-specific memory B cells—linked to long-term protection—are limited.
• What they did: In a randomized controlled trial, serotype-specific BMEM were measured by multimer spectral flow cytometry in subsets of N=50 per vaccine group per timepoint after 0+1 or 1+1 PCV10/PCV13, with blood collected at baseline (12 months) and day 7 and day 28 post-vaccination.
• The result: One or two doses produced BMEM at day 7 and day 28 for most serotypes; 1+1 increased BMEM at day 7 versus 0+1, but by day 28 schedule differences faded, and BMEM for 6B and 23F were detectable even without IgG ≥0.35 ug/mL.

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