Higher platelet counts are associated with migraine risk across three cohorts among more than 21,000 cases

Higher platelet counts are associated with increased migraine risk in the UK Biobank, with an OR of 1.058 per unit and replication in NHANES-FHS.

• Why it matters: Platelets may participate in migraine biology, but the relationship between baseline blood measures and migraine risk is not well defined across large populations.
• What they did: The study analyzed CBC data from UK Biobank baseline samples and migraine diagnoses, then replicated findings using NHANES exam-visit CBCs and Framingham Heart Study assessments.
• The result: Platelet count showed a UK Biobank association (OR=1.058, 95% CI [1.043,1.073], p=2.09E-14) and was replicated in NHANES-FHS meta-analysis (OR=1.074, 95% CI [1.025,1.126], p=0.003), supporting further longitudinal work.

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