Lipidome-wide analysis of concurrent and longitudinal blood pressure patterns in school-aged children

Each 1-SD increase in triglyceride TG 58:9 FA 22:4 is linked to 7.36 higher systolic BP percentile points in Belgian 9–12-year-olds.

• Why it matters: Elevated childhood blood pressure predicts later cardiovascular risk, yet the plasma lipid species tied to concurrent and changing BP phenotypes are not well defined.
• What they did: In the Belgian ENVIRONAGE birth cohort (195 children; 1,232 lipid species measured by LC-ESI-MS/MS), multivariable regression with permutation-based FWER correction tested associations with systolic and diastolic BP percentiles.
• The result: TG 58:9 FA 22:4 predicts incident (OR=2.78) and persistent (OR=2.14) elevated BP across longitudinal patterns, while lipid sets with total carbon number 38 (mainly PC and PE) show inverse enrichment with diastolic BP percentile.

AI summary of the abstract · may contain errors · not medical advice · read the paper.