The abstract is read at the publisher; the summary is JClub's.
HRG is elevated about 2.1-fold in plasma of free-living house sparrows (Passer domesticus) exposed to nickel–chromium contamination near the Doniambo smelter in Noumea.
- Why it matters: Ni and Cr toxicity in wildlife is poorly characterized, and there is a need for molecular biomarkers and mechanistic signatures in natural populations.
- What they did: Blood from 52 sparrows across 18 sites with different soil metal concentrations was profiled by LC-MS/MS in plasma and blood cell pellet fractions.
- The result: Ni–Cr co-exposure is linked to a coordinated nuclear toxicity pattern, including histone depletion, NUP153 dysregulation, and VRK1/TRIP13 upregulation, implying DNA damage response and genome maintenance disruption.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.