A shared wireless acquisition core for cortical and peripheral recordings in freely moving mice

An eight-channel wireless headstage for freely moving mice records six cortical and two neck-electrode channels with 0.176 V RMS noise (0.5–100 Hz) in a ~1.2 g setup.

• Why it matters: Freely moving experiments need simultaneous cortical, peripheral, and motion signals, but extra sensors can overload the headstage and complicate acquisition.
• What they did: The authors built a compact wireless acquisition core and used electrode reassignment to enable cardiac recording with the same electronics, then validated it in seizure and behavior cohorts.
• The result: In four chemically induced seizure mice, seizure detection achieved an overlap-based event F1 of 0.893 +/- 0.022 and pseudo-online updates took 46.394 +/- 0.363 ms, while separate recordings linked coherence patterns to movement and social behavior.

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