A Fibrous Optofluidic Probe for Endovascular Sensing of Blood Oxygenation and Flow Velocity

A flexible submillimeter fibrous optofluidic probe enables endovascular spectroscopic oximetry and fluorescence dilution velocimetry, capturing local oxygenation and flow-velocity changes in rabbit and canine arteries.

• Why it matters: Local hemodynamic measurements are needed to guide vascular interventions, but deep, narrow vessels make oxygenation and flow-velocity sensing difficult with conventional approaches.
• What they did: The device combines a polymer optical fiber for light delivery with a microfluidic tube for dye injection, supporting oximetry and fluorescence dilution-based velocimetry through one probe.
• The result: In rabbit arteries and during angiography-guided use in canine carotid arteries, it detects oxygenation and flow-velocity changes during occlusion and reperfusion that peripheral monitors do not reflect, enabling quantitative local monitoring.

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