Dual role of RBM3 in PEDV infection: stabilization of viral RNA and upregulation of the entry factor HSPA5

RBM3 promotes porcine epidemic diarrhea virus replication by binding the viral 3'UTR to prolong viral RNA half-life and by upregulating HSPA5 expression.

• Why it matters: PEDV replication depends on its genomic and subgenomic RNAs, yet the host RNA-binding proteins that stabilize these viral RNAs and coordinate entry-factor expression are not well defined.
• What they did: The study tested RBM3’s preference for the PEDV 3'UTR, measured effects on viral RNA stability, and assessed RBM3’s impact on HSPA5 promoter activity and HSPA5 mRNA levels.
• The result: RBM3 is identified as a positive host regulator of PEDV and a functional link between RBM3 and HSPA5 is established, suggesting RBM3 could be a target for antiviral intervention.

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