Evolution Shapes Cortical Interneuron Migration

Human cortical interneurons show slower migration with more leading-process branching and more homotypic repulsive interactions than mouse and ferret, promoting dispersed cortical invasion.

• Why it matters: Evolutionary differences in interneuron migration may underlie species-specific cortical development, but the cellular behaviors and mechanisms driving these divergent patterns were unclear.
• What they did: Comparative analyses across mouse, ferret, and human models identified a conserved migratory sequence with distinct migration behaviors; mechanistically, higher CCP1 expression in human cINs reduces microtubule glutamylation and doublecortin recruitment.
• The result: A CCP1-dependent mechanism regulates cIN dispersion, implying evolutionary tuning of migration can generate divergent cortical morphogenesis across mammals.

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