Fibronectin-Assisted Coating of Low-Molecular-Weight Fucoidan Creates a Biomimetic Interface for Endothelialization of Cobalt-Chromium Stents

Fibronectin-assisted LMWF coating on cobalt-chromium stents achieves a ten-fold higher surface density than LMWF alone (0.29 ± 0.04 vs 0.03 ± 0.01 μg/mm2).

• Why it matters: Incomplete or delayed endothelialization after stent placement can impair vascular healing and increase restenosis and late thrombosis risk.
• What they did: Co-Cr stents were coated with fibronectin plus low-molecular-weight fucoidan, then coating morphology, chemistry, wettability, and stability were measured and human endothelial cell behavior was tested.
• The result: The dual coating retained 0.27 ± 0.03 μg/mm2 after 168 h versus 0.01 ± 0.01 μg/mm2 for LMWF alone, and it enhanced adhesion, spreading, lamellipodia, proliferation, and MMP-2 secretion without detectable cytotoxicity or major inflammatory activation.

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