Msp300 Links Autophagy to Nuclear Morphodynamics

Msp300, a KASH-domain LINC complex protein in Drosophila melanogaster, directly interacts with autophagy protein Atg8a via a canonical LIR, linking autophagy to nuclear periphery dynamics.

• Why it matters: The connection between autophagy and nuclear architecture is unclear, despite autophagy’s role in stress adaptation and the LINC complex’s role in nuclear positioning.
• What they did: Yeast two-hybrid screening identified Atg8a–Msp300 isoforms E and G binding mediated by a canonical LC3-interacting region, and localization showed cytoplasmic and nuclear-periphery association under basal and elevated autophagy.
• The result: Stress assays indicate the Atg8a–Msp300 interaction influences events in and around the nucleus, supporting a functional link between autophagy and nuclear architecture at the nuclear periphery.

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