Enhancing deep sleep with auditory stimulation to boost cognitive training responsiveness in people with Parkinson's disease and mild cognitive impairment: Rationale and design of the double-blind randomized controlled trial PD-CogT-Sleep

PD-CogT-Sleep will test whether phase-targeted auditory stimulation added to digital cognitive training improves executive functions in people with Parkinson’s disease and mild cognitive impairment, targeting N=50.

• Why it matters: Cognitive training effects in PD and PD-MCI are small to moderate and vary widely between individuals, and deep sleep may help determine responsiveness and influence disease-related processes.
• What they did: In a monocentric, partly decentralized, double-blind randomized sham-controlled trial, participants are assigned 1:1 to CogT+PTAS or CogT+Sham, with outcomes measured at baseline, 5 weeks, and 3 months.
• The result: Executive functions are the primary endpoint, with additional cognitive measures, participant-reported outcomes, blood-based biomarkers, and high-density sleep EEG markers to assess whether PTAS strengthens CogT responsiveness and informs disease-modifying potential.

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