ACCURACY OF COMPRESSED SENSING ACCELERATED 3D-FLAIR IN THE DIAGNOSTIC WORK-UP OF MULTIPLE SCLEROSIS AT 1.5 T

Compressed sensing–accelerated 3D-FLAIR at 1.5T detects multiple sclerosis lesions non-inferiorly to optimized GRAPPA while cutting scan time by 31.8% (4:00 vs 5:52 minutes).

• Why it matters: Long 3D-FLAIR acquisition times limit MR-based MS diagnosis and monitoring, creating a need to shorten scans without losing lesion detection performance.
• What they did: In a single-center prospective non-inferiority study, optimized CS- and GRAPPA-accelerated 3D-FLAIR were compared in 68 patients with known or suspected MS, using manual lesion counts by two blinded readers with a 10% margin.
• The result: Non-inferiority for manual lesion count was shown for both readers (p < .0001 and p = .005), with excellent interrater agreement for CS (ICC = 0.921) and very good for GRAPPA (ICC = 0.851).

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