Elevated Maternal Glycated Albumin is Associated with Large for Gestational Age Infants: Results from a Prospective Longitudinal Study

Higher glycated albumin (GA-total) measured in stored maternal serum at 11–14 and 23–31 gestational weeks is associated with increased odds of large-for-gestational-age infants (OR=1.59, p=0.009).

• Why it matters: Glycated albumin predicts gestational diabetes mellitus, but its ability to flag adverse outcomes like fetal overgrowth beyond HbA1c is unclear.
• What they did: In a single-centre prospective cohort of 465 participants, GA was quantified by rapid liquid chromatography–tandem mass spectrometry at two sites (KQT, KLV) and summed (GA-total), with HbA1c measured routinely; logistic regression estimated odds for GDM and LGA.
• The result: GA-total was higher in the LGA group at both early (p=0.032) and mid-late pregnancy (p=0.030) and predicted LGA, while HbA1c showed no association with LGA at either timepoint.

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