Distinct medial septal GABAergic pathways differentially regulate spatial memory and network activity

Inhibition of septal PV+ versus CB+ projection pathways differentially affects spatial memory, with PV+ supporting reference memory and CB+ supporting both reference and working memory.

• Why it matters: Septal GABAergic neurons are linked to hippocampal function, but how distinct PV+ and CB+ projection routes map onto specific memory types and network dynamics is unclear.
• What they did: The study used pathway-specific inhibition to test memory performance and measured network activity, finding that septal PV+ neurons regulate theta oscillations.
• The result: PV+ projections to the dorsal hippocampus and MEC support reference memory, while CB+ projections to the MEC support both reference and working memory, and PV+ control theta rhythms.

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