SENgEAR: an interactive visualization platform for comparative analysis of senescence signatures and cellular communication

SENgEAR is a no-code web platform that unifies senescent cell annotation, cell-cell communication visualization, and cross-study comparison of senescence signatures across tissues, species, and modalities.

• Why it matters: Senescence signatures vary by context, and universal markers are lacking, making it hard to judge which signatures are specific and how they relate to cellular communication.
• What they did: The platform integrates senescent cell annotation with visualization of communication networks and comparative analysis of senescence signatures across studies, tissues, species, and data modalities.
• The result: SENgEAR enables exploration of contextual signature specificity, communication pathways, and senotype heterogeneity, demonstrated across aging, fibrosis, and wound healing states.

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